M&A Deal Summary

Neopharmed Gentili Acquires European Orladeyo Berotralstat business

On June 27, 2025, Neopharmed Gentili acquired life science company European Orladeyo Berotralstat business from BioCryst Pharmaceuticals for 264M USD

Acquisition Highlights
  • This is Neopharmed Gentili’s 2nd transaction in the Life Science sector.
  • This is Neopharmed Gentili’s largest (disclosed) transaction.
  • This is Neopharmed Gentili’s 1st transaction in the United States.
  • This is Neopharmed Gentili’s 1st transaction in North Carolina.

M&A Deal Summary

Date 2025-06-27
Target European Orladeyo Berotralstat business
Sector Life Science
Buyer(s) Neopharmed Gentili
Sellers(s) BioCryst Pharmaceuticals
Deal Type Divestiture
Deal Value 264M USD

Target

European Orladeyo Berotralstat business

Durham, North Carolina, United States
European Orladeyo Berotralstat business offers a focused portfolio and infrastructure dedicated to the prevention of hereditary angioedema attacks. European Orladeyo Berotralstat business is based in Durham, North Carolina.

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Buyer(S) 1

Buyer

Neopharmed Gentili

Milan, Italy

Category Company
Founded 2011
Sector Life Science
Revenue 192M EUR (2017)
DESCRIPTION

Neopharmed Gentili is an Italian pharmaceutical group focused on the research, development, production, and distribution of medicines in many therapeutic areas such as vascular and cardio-metabolic areas, pneumatological areas, antibiotics, OTCs, and supplements. Neopharmed Gentili was founded in 2011 and is based in Milan, Italy.


DEAL STATS #
Overall 2 of 2
Sector: Life Science M&A 2 of 2
Type: Divestiture M&A Deals 1 of 1
State: North Carolina M&A 1 of 1
Country: United States M&A 1 of 1
Year: 2025 M&A 1 of 1
Size (of disclosed) 1 of 1
PREVIOUS DEAL
DATE TARGET DEAL TYPE VALUE
2019-10-31 MDM

Monza, Italy

MDM S.p.A. a pharmaceutical company based in Monza active in the distribution of pharmaceuticals, nutraceuticals and medical devices for neurology and orthopedics.

Buy -

Seller(S) 1

SELLER

BioCryst Pharmaceuticals

Durham, North Carolina, United States

Category Company
Founded 1986
Sector Life Science
Employees580
Revenue 451M USD (2024)
DESCRIPTION

BioCryst Pharmaceuticals designs, optimizes and develops novel small molecule drugs that block key enzymes involved in rare diseases. BioCryst Pharmaceuticals was founded in 1986 and is based in Durham, North Carolina.


DEAL STATS #
Overall 1 of 1
Sector: Life Science M&A 1 of 1
Type: Divestiture M&A Deals 1 of 1
State: North Carolina M&A 1 of 1
Country: United States M&A 1 of 1
Year: 2025 M&A 1 of 1
Size (of disclosed) 1 of 1
PREVIOUS DEAL
DATE TARGET DEAL TYPE VALUE
2012-10-18 Presidio Pharmaceuticals

San Francisco, California, United States

Presidio Pharmaceuticals is a specialty pharmaceutical company focusing on in-licensing, developing, and commercializing novel and validated therapeutics for chronic viral infections, including HIV-1, HCV, and CMV. Presidio Pharmaceuticals was founded in 2006 and is based in San Francisco, California.

Buy $101M
FOLLOWING DEAL
DATE TARGET DEAL TYPE VALUE
2025-10-14 Astria

Boston, Massachusetts, United States

Astria is a biopharmaceutical company focused on developing life-changing therapies for allergic and immunologic diseases. The company's lead program, navenibart (STAR-0215), is a monoclonal antibody inhibitor of plasma kallikrein in clinical development for the treatment of hereditary angioedema. Its second program, STAR-0310, is an investigational monoclonal antibody OX40 antagonist in clinical development for the treatment of atopic dermatitis. Astria was founded in 2008 and is based in Boston, Massachusetts.

Buy $700M